McClellan J, Sikich L, Findling RL, et al. Accessed November 23, 2019. Accessed February 25, 2020. Schwartz MD, Canales JJ, Zucchi R, Espinoza S, Sukhanov I, Gainetdinov RR. Emerging Evidence on Genetics of Schizophrenia Raises Hopes for New Treatment Targets Journal of Clinical Psychopharmacology Presents Translational Science Update . PANSS Total Score Change from Baseline … October 9, 2020. In some cases, hospitalization may be needed. acmigold15; October 11, 2020 ; Blog; 0 ... Research into the treatment of schizophrenia is long overdue, as it can be a devastating disease process. The agent is an antagonist of σ-2 and 5-HT2A and has a low affinity for dopaminergic, muscarinic, cholinergic, and histaminergic receptors.44,45 A phase 3, randomized, double-blind, placebo-controlled, parallel-group trial evaluating the efficacy and safety of roluperidone in 501 adult patients with negative symptoms of schizophrenia is currently underway.46 The primary objective is to evaluate the efficacy of 32 mg/day and 64 mg/day of roluperidone compared with placebo over 12 weeks via change in PANSS Marder negative symptoms factor score. Madrid, Spain: Laboratorios Farmacéuticos ROVI; March 19, 2019. edisongroup.com/publication/doria-phase-iii-trial-hits-primary-endpoint/23705. Metformin for weight loss and metabolic control in overweight outpatients with schizophrenia and schizoaffective disorder. Dublin, Ireland: Alkermes; November 29, 2018. prnewswire.com/news-releases/alkermes-announces-positive-topline-results-from-enlighten-2-phase-3-study-of-alks-3831-in-patients-with-schizophrenia-300757319.html. Share . Currently available antipsychotics, which are thought to work primarily via modulation of dopamine, largely target positive symptoms.4 As a result, many patients are left with residual negative and cognitive symptoms.4 To address these gaps in therapy, new research combined with an increased understanding of the etiology and pathophysiology of schizophrenia is leading to the development of novel agents with the goal of improving schizophrenia management. Treatment with medications and psychosocial therapy can help manage the condition. A Study of ALKS 3831 in Adults With Schizophrenia (The ENLIGHTEN-2 Study). WASHINGTON, D.C., Sept. 1, 2020 – The American Psychiatric Association (APA) today released a new evidence-based practice guideline to enhance the treatment of patients with schizophrenia. Anticholinergic medications (eg, benztropine) can be added to the current regimen to address acute dystonia or pseudoparkinsonism; however, they can cause additional AEs such as dry mouth, blurred vision, and constipation.13 Benzodiazepines or β-blockers, such as propranolol, may be prescribed to help manage akathisia.12,13, TD is defined by abnormal movements that emerge after months or years of treatment with an antipsychotic medication.18 The movements are usually slow and athetoid or rapid choreiform jerks; both types of movements commonly manifest in the mouth, face, jaw, tongue, hands, or feet.13 The strategy for managing TD is to lower the dose of the antipsychotic drug or to change to quetiapine or clozapine, which are associated with a lower risk of TD symptoms than other antipsychotic drugs.18 Additionally, vesicular monoamine transporter 2 inhibitors may be used to help manage symptoms of TD.19, NMS is a rare but potentially life-threatening AE typically seen within the first month of antipsychotic treatment. About half were randomly assigned to take SEP-363856 capsules once a day, while the rest received placebo capsules. If it proves safe and effective, Goff said that one future question will be whether it can help people who have failed to respond to standard antipsychotics. The American Psychiatric Association (APA) has released a new evidence-based practice guideline for the treatment of schizophrenia. Effectiveness of antipsychotics in first-episode schizophrenia and schizophreniform disorder on response and remission: an open randomized clinical trial (EUFEST). But, Goff said, they do not ease the "negative" symptoms that plague people with schizophrenia. Clinical guidance on the identification and management of treatment-resistant schizophrenia. No statistically significant changes emerged in EPS, body weight, lipids, glucose, or prolactin.29 The most common AEs were somnolence, with 17.3% versus 4.0% with lumateperone and placebo, respectively; mild sedation (12.0% vs 5.4%); and fatigue (5.3% vs 1.3%).29, The second phase 3 trial, ITI-007-302, was a multicenter, randomized, double-blind, fixed-dose, placebo- and active-controlled inpatient study conducted in 696 patients.30 Participants were randomized (1:1:1:1) to either lumateperone 60 or 20 mg, risperidone 4 mg as the active control, or placebo once daily in the morning for 6 weeks.27 Neither dose of lumateperone separated from placebo, whereas risperidone did. That compared with 44% of patients given a placebo. Methotrexate is often used to treat inflammatory diseases such as rheumatoid arthritis and Crohn's disease. Lumateperone 60 mg/day demonstrated statistically significant superiority in the change in the Positive and Negative Syndrome Scale (PANSS) total score versus placebo, with a least squares mean change from baseline on the PANSS total score of —14.5 points versus –10.3 points with placebo (P = .022). Marlborough, MA, and Paramus, NJ: Sunovion Pharmaceuticals Inc and PsychoGenics Inc; September 27, 2019. news.sunovion.com/press-release/sunovion-and-psychogenics-initiate-diamond-phase-3-clinical-studies-sep-363856. 5 days ago. The oral pill from Intra-Cellular Therapies should be available in early 2020. This may be done to help rule out other problems that could be causing symptoms and to check for any related complications. 2020 | 15:14. However, a new treatment using the deep brain stimulation technique could improve the condition of patients. These include severe neutropenia or agranulocytosis and cardiac complications, such as myocarditis or cardiomyopathy.13, First- and Second-Generation Antipsychotic AE Overview, Early in the course of treatment with antipsychotics, common AEs include sedation, orthostatic changes in blood pressure, and anticholinergic AEs such as dry mouth, constipation, and difficulty with urination.12 Prolongation of the QTc interval can also be a concern because of the potential for life-threatening torsades de pointes.12, Akathisia is the most common EPS seen in patients treated with antipsychotics.13 It presents as restless movements, and patients may describe a sense of inner restlessness. WASHINGTON, D.C., Sept. 1, 2020 – The American Psychiatric Association (APA) today released a new evidence-based practice guideline to enhance the treatment of patients with schizophrenia… The first medications for schizophrenia were discovered serendipitously in the 1950s, with subsequent “me-too” drugs targeting the same limited number of neurotransmitters. In the double-blind phase, patients will receive either paliperidone every 3 months or paliperidone every 6 months. The increased prolactin may result in galactorrhea and menstrual disturbances in women and sexual dysfunction and gynecomastia in men, which can contribute to medication nonadherence.13 Long-term effects of hyperprolactinemia may include an increased risk of osteoporosis and breast or endometrial cancer.12 Switching to a medication with a lower risk for hyperprolactinemia may be advisable if patients are affected by elevations in prolactin.22, Novel Treatment Strategies and Emerging Agents for Schizophrenia. 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